Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …

Simple Summary Colorectal cancer is the third most commonly diagnosed cancer. Patients
may receive chemotherapy, targeted therapy, immunotherapy, radiotherapy, and/or surgery …

Objectives In biobanking based on patient-derived organoids (PDO), the genetic stability of
organoid lines is critical for the clinical relevance of PDO with parental tumors. However …

Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or
disease from which they are derived. Due to their stem cell origin, organoids contain a …

Simple Summary Because of the limitations of current in vivo and in vitro models, this review
considers a human relevant approach: modeling colorectal radiotoxicity through human …

Abnormal expression of long non-coding RNAs (lncRNAs) plays an essential role in various
malignant neoplasia. As a newly identified lncRNA, LINC01234 is abnormally expressed in …

The recurrence of colorectal liver metastasis (CRLM) following liver resection is common;
approximately 40% of patients will experience tumor recurrence post-surgery. Renin …

Purpose Tissue confirmation of pancreatobiliary cancer is often difficult because of the
location of the tumor and structure of the surrounding blood vessels. Patient-derived cancer …

The review summarizes innovative advances in the field of organoids as a tool for accurate
cancer modeling. The conditions for reproducing the microenvironment in vitro based on …