For several decades there has been accumulating evidence implicating type I interferons
(IFNs) as key elements of the immune response. Therapeutic approaches incorporating …

Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …

Abstract Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA
endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in …

Usutu virus (USUV) and West Nile virus (WNV) are two closely related emerging mosquito-
borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe …

DNA-damaging agents exploit increased genomic instability, a hallmark of cancer. Recently,
inhibitors targeting the DNA damage response (DDR) pathways, such as PARP inhibitors …

Intrinsic antiviral host factors confer cellular defence by limiting virus replication and are
often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral …

Abstract Schlafen11 (SLFN11) inactivation occurs in approximately 50% of cancer cell lines
and in a large fraction of patient tumor samples, which leads to chemoresistance. Therefore …

Type I interferons (IFN‐I) are a group of related proteins that help regulate the activity of the
immune system and play a key role in host defense against viral infections. Upon infection …

Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the
mechanisms that contribute to the maintenance of HIV-1 latency are incompletely …

Host restriction factors affect different phases of a viral life cycle, contributing to innate
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …