Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Type VII secretion systems: structure, functions and transport models

A Rivera-Calzada, N Famelis, O Llorca… - Nature Reviews …, 2021 - nature.com
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

In-cell NMR: Why and how?

FX Theillet, E Luchinat - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Nucleotide sugars in chemistry and biology

S Mikkola - Molecules, 2020 - mdpi.com
Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

NC Poulton, JM Rock - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Transporters involved in the biogenesis and functionalization of the mycobacterial cell envelope

M Jackson, CM Stevens, L Zhang, HI Zgurskaya… - Chemical …, 2020 - ACS Publications
The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …

Monoclonal antibodies to lipoarabinomannan/arabinomannan–characteristics and implications for tuberculosis research and diagnostics

DT Corrigan, E Ishida, D Chatterjee, TL Lowary… - Trends in …, 2023 - cell.com
Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related
capsular polysaccharide arabinomannan (AM) are increasingly important for investigations …

Mycobacterial membrane protein large 3 (MmpL3) inhibitors: a promising approach to combat tuberculosis

MD Umare, PB Khedekar, RV Chikhale - ChemMedChem, 2021 - Wiley Online Library
Tuberculosis is a prominent aliment throughout the world and a leading cause of mortality
among infectious diseases. Drug development for multi‐drug resistance and reducing the …