Nuclear-Targeting Lipid PtIV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing …
D Wei, J Fan, J Yan, C Liu, J Cao, C Xu… - Journal of the …, 2023 - ACS Publications
Patients treated with Pt-based anticancer drugs (PtII) often experience severe side effects
and are susceptible to cancer recurrence due to the limited bioavailability of PtII and tumor …
and are susceptible to cancer recurrence due to the limited bioavailability of PtII and tumor …
The current status in computational exploration of Pt (iv) prodrug activation by reduction
Octahedral PtIV complexes are considered highly promising candidates for overcoming
some shortcomings of clinically approved PtII drugs. PtIV compounds, owing to their inertia …
some shortcomings of clinically approved PtII drugs. PtIV compounds, owing to their inertia …
Pt (IV) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?
A Lopez-Sanchez, H Bertrand - Inorganic Chemistry Frontiers, 2024 - pubs.rsc.org
Cancer remains a significant global health challenge, necessitating continuous
advancements in therapeutic strategies. Chemotherapeutic agents have long been pivotal in …
advancements in therapeutic strategies. Chemotherapeutic agents have long been pivotal in …
Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and …
XL Li, MF Wang, LZ Zeng, GK Li… - Angewandte Chemie …, 2024 - Wiley Online Library
A planar conjugated ligand functionalized with bithiophene and its Ru (II), Os (II), and Ir (III)
complexes have been constructed as single‐molecule platform for synergistic …
complexes have been constructed as single‐molecule platform for synergistic …
Alendronate PtIV Prodrug Amphiphile for Enhanced Chemotherapy Targeting and Bone Destruction Inhibition in Osteosarcoma
K Sun, L Yuan, S Chen, Y Sun… - Advanced Healthcare …, 2024 - Wiley Online Library
Chemotherapy remains the primary treatment method for osteosarcoma after surgery.
However, the lack of selectivity of chemotherapy for osteosarcoma leads to unpredictable …
However, the lack of selectivity of chemotherapy for osteosarcoma leads to unpredictable …
Synthesis and anticancer mechanisms of four novel platinum (ii) 4′-substituted-2, 2′: 6′, 2′′-terpyridine complexes
CJ Liang, RC Wu, XQ Huang, QP Qin, H Liang… - Dalton …, 2024 - pubs.rsc.org
Mitophagy, a selective autophagic process, has emerged as a pathway involved in
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …
Ruthenium complexes bearing nile red chromophore and one of its derivative: Theoretical evaluation of PDT‐related properties
The outcomes of DFT‐based calculations are here reported to assess the applicability of two
synthesized polypyridyl Ru (II) complexes, bearing ethynyl nile red (NR) on a bpy ligand …
synthesized polypyridyl Ru (II) complexes, bearing ethynyl nile red (NR) on a bpy ligand …
Highly photoactive Ir (iii)–Pt (iv) heterometallic conjugates for anticancer therapy
W Hu, R Liu, K Zheng, Z Wang - Chemical Communications, 2024 - pubs.rsc.org
For the first time, this study reported the photoactivatable activity of Ir (III)–Pt (IV)
heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin …
heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin …
Computational Assessment of Novel Ruthenium Phenoxazine‐Based Complexes as Photosensitizers in Photodynamic Therapy
A computational examination of two new polypyridyl ruthenium complexes, containing
meldola blue (MDB) and nile blue (NB) chromophores, is here reported in order to assess …
meldola blue (MDB) and nile blue (NB) chromophores, is here reported in order to assess …
Alloxazine-Based Ligands and Their Ruthenium Complexes as NADH Oxidation Catalysts and G4 Binders
MJ Móran Plata, L Marretta, L Gaztelumendi… - Inorganic …, 2024 - ACS Publications
Flavin-like ligands (L-1 and L-2) with extended π-conjugation were synthesized using
microwave-assisted techniques. An N, N-chelating fragment was integrated into alloxazine …
microwave-assisted techniques. An N, N-chelating fragment was integrated into alloxazine …