Nuclear-Targeting Lipid PtIV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing …

D Wei, J Fan, J Yan, C Liu, J Cao, C Xu… - Journal of the …, 2023 - ACS Publications
Patients treated with Pt-based anticancer drugs (PtII) often experience severe side effects
and are susceptible to cancer recurrence due to the limited bioavailability of PtII and tumor …

The current status in computational exploration of Pt (iv) prodrug activation by reduction

F Ponte, S Scoditti, G Mazzone, E Sicilia - … Chemistry Chemical Physics, 2023 - pubs.rsc.org
Octahedral PtIV complexes are considered highly promising candidates for overcoming
some shortcomings of clinically approved PtII drugs. PtIV compounds, owing to their inertia …

Pt (IV) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

A Lopez-Sanchez, H Bertrand - Inorganic Chemistry Frontiers, 2024 - pubs.rsc.org
Cancer remains a significant global health challenge, necessitating continuous
advancements in therapeutic strategies. Chemotherapeutic agents have long been pivotal in …

Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and …

XL Li, MF Wang, LZ Zeng, GK Li… - Angewandte Chemie …, 2024 - Wiley Online Library
A planar conjugated ligand functionalized with bithiophene and its Ru (II), Os (II), and Ir (III)
complexes have been constructed as single‐molecule platform for synergistic …

Alendronate PtIV Prodrug Amphiphile for Enhanced Chemotherapy Targeting and Bone Destruction Inhibition in Osteosarcoma

K Sun, L Yuan, S Chen, Y Sun… - Advanced Healthcare …, 2024 - Wiley Online Library
Chemotherapy remains the primary treatment method for osteosarcoma after surgery.
However, the lack of selectivity of chemotherapy for osteosarcoma leads to unpredictable …

Synthesis and anticancer mechanisms of four novel platinum (ii) 4′-substituted-2, 2′: 6′, 2′′-terpyridine complexes

CJ Liang, RC Wu, XQ Huang, QP Qin, H Liang… - Dalton …, 2024 - pubs.rsc.org
Mitophagy, a selective autophagic process, has emerged as a pathway involved in
degrading dysfunctional mitochondria. Herein, new platinum (II)-based chemotherapeutics …

Ruthenium complexes bearing nile red chromophore and one of its derivative: Theoretical evaluation of PDT‐related properties

P Barretta, S Scoditti, D Belletto, F Ponte… - Journal of …, 2024 - Wiley Online Library
The outcomes of DFT‐based calculations are here reported to assess the applicability of two
synthesized polypyridyl Ru (II) complexes, bearing ethynyl nile red (NR) on a bpy ligand …

Highly photoactive Ir (iii)–Pt (iv) heterometallic conjugates for anticancer therapy

W Hu, R Liu, K Zheng, Z Wang - Chemical Communications, 2024 - pubs.rsc.org
For the first time, this study reported the photoactivatable activity of Ir (III)–Pt (IV)
heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin …

Computational Assessment of Novel Ruthenium Phenoxazine‐Based Complexes as Photosensitizers in Photodynamic Therapy

P Barretta, F Ponte, S Scoditti… - European Journal of …, 2024 - Wiley Online Library
A computational examination of two new polypyridyl ruthenium complexes, containing
meldola blue (MDB) and nile blue (NB) chromophores, is here reported in order to assess …

Alloxazine-Based Ligands and Their Ruthenium Complexes as NADH Oxidation Catalysts and G4 Binders

MJ Móran Plata, L Marretta, L Gaztelumendi… - Inorganic …, 2024 - ACS Publications
Flavin-like ligands (L-1 and L-2) with extended π-conjugation were synthesized using
microwave-assisted techniques. An N, N-chelating fragment was integrated into alloxazine …