3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …

There has been enormous progress during the last few years in the determination of three-
dimensional biological structures by single particle electron cryomicroscopy (cryoEM) …

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron
microscopy | Nature Methods Skip to main content Thank you for visiting nature.com. You are …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …

INTRODUCTION Synthetic DNA can be programmed by using canonical Watson-Crick base
pairing to form highly structured nanometer-scale assemblies that rival many natural protein …

Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of
validation metrics to independently assess map quality and model geometry. We report …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined …

Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from
the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that …

Cryo–electron microscopy (cryo-EM) is rapidly emerging as a powerful tool for protein
structure determination at high resolution. Here we report the structure of a complex …

The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a
G4C2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with …