Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Prokaryotes have numerous mobile genetic elements (MGEs) that mediate horizontal gene
transfer (HGT) between cells. These elements can be costly, even deadly, and cells use …

Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …

CRISPR loci and Cas proteins provide adaptive immunity in prokaryotes against invading
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …

The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

The CRISPR-Cas are adaptive bacterial and archaeal immunity systems that have been
harnessed for the development of powerful genome editing and engineering tools. In the …

Bacteria have evolved a multitude of systems to prevent invasion by bacteriophages and
other mobile genetic elements. Comparative genomics suggests that genes encoding …

Phage therapy was implemented almost a century ago but was subsequently abandoned
when antibiotics emerged. However, the rapid emergence of drug-resistant, which has …

Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …