Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Galactofuranose (Gal f) is the five-membered ring form of galactose. It is widely distributed
among several branches of the eukaryotic kingdom. This review highlights recent advances …

We report that simple glycoside donors can drastically shift the equilibria of
glycosyltransferase-catalyzed reactions, transforming NDP-sugar formation from an …

Nucleotide sugars are the key precursors for all glycosylation reactions and are required
both for oligo-and polysaccharides synthesis and protein and lipid glycosylation. Among all …

Glycoconjugates are important mediators of host-pathogen interactions and are usually very
abundant in the surface of many protozoan parasites. However, in the particular case of …

Carbohydrate structures play important roles in many biological processes, including cell
adhesion, cell-cell communication, and host-pathogen interactions. Sugar nucleotides are …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Oligosaccharides and polysaccharides constitute the principal components of
carbohydrates, which are important biomacromolecules that demonstrate considerable …

Dysregulated metabolism is a hallmark of cancer that supports tumor growth and metastasis.
One understudied aspect of cancer metabolism is altered nucleotide sugar biosynthesis …

Simple sugars (eg Glc, Gal) are the building blocks of disaccharides (eg Suc) and
polysaccharides (eg cellulose, hemicellulose). To produce disaccharides and …