Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …

Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine
metabolic communication is not described. We found that EC-specific loss of the glycolytic …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Innate immune responses, particularly activation of macrophages and microglia, are
increasingly implicated in CNS disorders. It is now appreciated that the heterogeneity of …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Approximately 10% of bone fractures do not heal satisfactorily, leading to significant clinical
and socioeconomic implications. Recently, the role of macrophages in regulating bone …

Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …