Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen
S Yang, F Zhang, J Ma, W Ding - Ageing research reviews, 2020 - Elsevier
As an important part of the spinal column, the intervertebral disc (IVD) plays an important
role in the intervertebral juncture and spinal movement in general. IVD degeneration (IVDD) …
role in the intervertebral juncture and spinal movement in general. IVD degeneration (IVDD) …
[HTML][HTML] The immune privilege of the intervertebral disc: implications for intervertebral disc degeneration treatment
Z Sun, B Liu, ZJ Luo - International journal of medical sciences, 2020 - ncbi.nlm.nih.gov
The intervertebral disc (IVD) is the largest avascular organ of the body. It is composed of
three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous …
three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous …
Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs
S Molladavoodi, J McMorran, D Gregory - Cell and Tissue Research, 2020 - Springer
Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …
population. It is the number one cause of disability worldwide and has enormous …
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …
overlooked. We have shown that NP cells contain networked mitochondria and that …
Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies
OM Torre, V Mroz, MK Bartelstein… - Annals of the New …, 2019 - Wiley Online Library
Despite considerable efforts to develop cellular, molecular, and structural repair strategies
and restore intervertebral disk function after injury, the basic biology underlying …
and restore intervertebral disk function after injury, the basic biology underlying …
[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration
Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …
and imposes heavy economic burden on the society, while it is greatly attributed to …
[HTML][HTML] Updates on pathophysiology of discogenic back pain
Discogenic back pain, a subset of chronic back pain, is caused by intervertebral disc (IVD)
degeneration, and imparts a notable socioeconomic health burden on the population …
degeneration, and imparts a notable socioeconomic health burden on the population …
[HTML][HTML] Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
There is a well-established link between cytokine expression and the progression of
intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor …
intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor …
Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases
Intervertebral disc (IVD) degeneration is a major contributing factor to chronic low back pain
and disability, leading to imbalance between anabolic and catabolic processes, altered …
and disability, leading to imbalance between anabolic and catabolic processes, altered …
AF cell derived exosomes regulate endothelial cell migration and inflammation: Implications for vascularization in intervertebral disc degeneration
Z Sun, H Zhao, B Liu, Y Gao, WH Tang, ZH Liu, ZJ Luo - Life Sciences, 2021 - Elsevier
Aims The intervertebral disc is the largest avascular organ of the body. Vascularization of the
disc has been typically regarded as a pathological feature of intervertebral disc …
disc has been typically regarded as a pathological feature of intervertebral disc …