Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in
both men and women worldwide. This is in spite of widespread, effective measures of …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water …

BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …

Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing
DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor …

Oxaliplatin, a diaminocyclohexane-containing platinum, has a spectrum of activity and
mechanisms of action and resistance that appear to be different from those of other platinum …

PURPOSE: To test the hypotheses of whether the relative mRNA expression of the
thymidylate synthase (TS) gene and the excision cross-complementing (ERCC1) gene are …

Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have
similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The …