SEM/EDX and Raman chemical imaging of pharmaceutical tablets: A comparison of tablet surface preparation and analysis methods

S Gupta, T Omar, FJ Muzzio - International Journal of Pharmaceutics, 2022 - Elsevier
A better understanding of a pharmaceutical tablet's microstructure has the potential to unlock
the black box between material attributes, process parameters and the critical quality …

Application of a wavelength angle mapper for variable selection in iterative optimization technology predictions of drug content in pharmaceutical powder mixtures

AJ Rish, SR Henson, NL Velez-Silva, MN Hasan… - International Journal of …, 2023 - Elsevier
Process analytical technology (PAT) is an essential tool within pharmaceutical
manufacturing to ensure consistent quality and maintain process control. Near-infrared (NIR) …

Topologically directed confocal Raman imaging (TD-CRI): Advanced Raman imaging towards compositional and micromeritic profiling of a commercial tablet …

P Muthudoss, S Kumar, EYC Ann, KJ Young… - … of Pharmaceutical and …, 2022 - Elsevier
Particle size distribution (PSD), spatial location and particle cluster size of ingredients,
polymorphism, compositional distribution of a pharmaceutical product are few of the most …

[HTML][HTML] Evaluation of the miscibility of novel cocoa butter equivalents by Raman mapping and multivariate curve resolution–alternating least squares

EM Castro-Alayo, L Torrejón-Valqui, IS Cayo-Colca… - Foods, 2021 - mdpi.com
Cocoa butter (CB) is an ingredient traditionally used in the manufacturing of chocolates, but
its availability is decreasing due to its scarcity and high cost. For this reason, other vegetable …

Multi-layer Raman chemical mapping to investigate the effect of API particle size and blending shear rate on API domain sizes in pharmaceutical tablets

S Gupta, B Igne, T Omar, AD Román-Ospino… - International Journal of …, 2022 - Elsevier
While macromixing (gross uniformity) has received a lot of attention in pharmaceutical
powder blending, micromixing (particularly, particle-level aggregation) has been …

Development of iterative optimization technology: Selecting pure component spectra using a small-scale feed frame simulator

S Henson, AJ Rish, MA Alam, Y Liu, JK Drennen… - International Journal of …, 2024 - Elsevier
The application of spectroscopic process analytical technology (PAT) for in-line data
collection offers advantages to modern pharmaceutical manufacturing. Partial least squares …

A novel approach in pharmaceutical analysis by laser induced breakdown spectroscopy combined with chemometric methods and artificial neural network

AH Farhadian, SS Mousavifard, M Mollaei - Laser Physics, 2022 - iopscience.iop.org
As a reliable method, Laser induced breakdown spectroscopy (LIBS) is widely applied to
elemental analysis in different fields. In this research, LIBS was used to analyze …

Spatially offset Raman scattering line-mapping as an adaptive tool ensuring accuracy for determination of component concentrations in tablets with different particle …

S Cho, JI Jang, HM Kim, J Kim, H Chung - Spectrochimica Acta Part A …, 2024 - Elsevier
Spatially offset Raman scattering (SORS) line-mapping was explored as a versatile tool to
examine accuracy variations in compositional analyses of tablets with different particle sizes …

MODELLING AND SIMULATION OF NONLINEAR DYNAMIC FLOW FIELD AND TEMPERATURE FIELD OF DEPYROGENATION TUNNEL

Y Wang, Q Zhu, T Huang, X Han… - Facta Universitatis …, 2024 - casopisi.junis.ni.ac.rs
Nonlinear dynamics plays a crucial role particularly in equipment validation of preparation
production, validation results of which will significantly influence the results and period of …