Absorption and metabolism of flavonoids

T Walle - Free radical biology and medicine, 2004 - Elsevier
The benefits of flavonoids as chemopreventive dietary or dietary supplemental agents are
still only “potential.” Much has been learned about possible mechanisms of action of these …

Role of cytochrome P450 2C8 in drug metabolism and interactions

JT Backman, AM Filppula, M Niemi… - Pharmacological reviews, 2016 - ASPET
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …

A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors

L Li, X Yan, F Chen, L Zheng, Y Hu, F He… - … Reviews in Food …, 2023 - Wiley Online Library
Citrus is an important source of flavonoids in our daily diet. Citrus flavonoids have
antioxidant, anticancer, anti‐inflammatory, and cardiovascular disease prevention functions …

Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury

SB Subramanya, B Venkataraman… - International journal of …, 2018 - mdpi.com
Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is
a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic …

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2

SF Zhou, B Wang, LP Yang, JP Liu - Drug metabolism reviews, 2010 - Taylor & Francis
Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME

Z Yang, K Kulkarni, W Zhu, M Hu - Anti-Cancer Agents in …, 2012 - ingentaconnect.com
Genistein, one of the most active natural flavonoids, exerts various biological effects
including chemoprevention, antioxidation, antiproliferation and anticancer. More than 30 …

Flavonoid–drug interactions: effects of flavonoids on ABC transporters

ME Morris, S Zhang - Life sciences, 2006 - Elsevier
Flavonoids are present in fruits, vegetables and beverages derived from plants (tea, red
wine), and in many dietary supplements or herbal remedies including Ginkgo Biloba, Soy …

Genistein: Dual role in women's health

L Yu, E Rios, L Castro, J Liu, Y Yan, D Dixon - Nutrients, 2021 - mdpi.com
Advanced research in recent years has revealed the important role of nutrients in the
protection of women's health and in the prevention of women's diseases. Genistein is a …

Dietary flavonoids for immunoregulation and cancer: Food design for targeting disease

JH Ahn-Jarvis, A Parihar, AI Doseff - Antioxidants, 2019 - mdpi.com
Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables,
have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and …

Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes

VP Androutsopoulos, A Papakyriakou… - Pharmacology & …, 2010 - Elsevier
Flavonoids are polyphenolic compounds that have attracted the attention of the scientific
community as the hallmark molecules responsible for cancer prevention by a plethora of …