Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by
regeneration depends on the cellular and molecular events of Wallerian degeneration that …

Abstract Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell
differentiation factor, capable of inducing the maturation of B cells into antibody-producing …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

Abstract Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system,
but also acts in other biological systems and many physiological events in various organs. In …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …