Within a multi-celled organism, regulation and organization require that biological signals be
transmitted from one cell to another, across cell membranes. Such is the case with growth …

During the purification of nerve growth factor from mouse submaxillary glands by
carboxymethyl cellulose chromatography, distinct biological activities were noticed when a …

CD4 is crucial for antigen-driven helper T cell signaling and is used as receptor by the
human immunodeficiency virus (HIV). The HIV early protein Nef causes a loss of CD4 from …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

The aggregation states of the epidermal growth factor receptor (EGFR) on single A431
human epidermoid carcinoma cells were assessed with two new techniques for determining …

The initiation of epidermal growth factor receptor (EGFR) kinase activity proceeds via an
asymmetric dimerization mechanism in which a “donor” tyrosine kinase domain (TKD) …

The second edition of Structure in Protein Chemistry showcases the latest developments
and innovations in the field of protein structure analysis and prediction. The book begins by …

Emerging lines of evidence suggest that in addition to growth factors, the process of
colorectal tumorigenesis may also be driven by the upregulation of the inducible form of …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

The tyrosine kinase inhibitor gefitinib inhibits growth in some tumor types by targeting the
epidermal growth factor receptor (EGFR). Previous studies show that the affinity of the EGF …