Evidence is reviewed for a developmentally‐emerging behavioral phenotype in individuals
with Down syndrome that includes significant delay in nonverbal cognitive development …

At present, there may be over 210,000 people with Down syndrome (DS) over the age of 55
in the United States (US) who have significant needs for augmented services due to …

Down syndrome (DS) is a major cause of mental retardation and congenital heart disease.
Besides a characteristic set of facial and physical features, DS is associated with congenital …

Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down
syndrome (DS) has been linked to increased brain amyloid levels and early-onset …

Hydrogen sulfide (H 2 S) is a well-known toxic gas with the smell of rotten eggs. Since the
first description of the toxicity of H 2 S in 1713, most studies about H 2 S have been devoted …

Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21)
and is the most common genetic cause of significant intellectual disability. In addition to …

Abstract To determine which regions of chromosome 21 are involved in the pathogenesis of
specific features of Down syndrome, we analysed, phenotypically and molecularly, 10 …

Trisomy 21 or Down syndrome is a chromosomal disorder resulting from the presence of all
or part of an extra Chromosome 21. It is a common birth defect, the most frequent and most …

Down syndrome (DS) is characterized by increased mortality rates, both during early and
later stages of life, and age‐specific mortality risk remains higher in adults with DS …

Down syndrome (DS) is one of the most frequent congenital birth defects, and the most
common genetic cause of mental retardation. In most cases, DS results from the presence of …