Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past,
elesclomol was recognized as an inducer of oxidative stress, but now it has also been found …

Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal
gynaecological malignancy in the Western world. Therapeutic approaches need to account …

The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Cluster of differentiation 24 (CD24) is a small, highly glycosylated cell adhesion protein that
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …

Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …

CD44, an adhesion molecule that binds to the extracellular matrix, primarily to hyaluronan
(HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also …