Betulin and betulinic acid: Triterpenoids derivatives with a powerful biological potential
A Hordyjewska, A Ostapiuk, A Horecka… - Phytochemistry …, 2019 - Springer
Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …
Betulin and its derivatives as novel compounds with different pharmacological effects
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022
Covering: 2018 to 2022 Antimicrobial resistance (AMR) poses a significant global health
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …
Pharmacological potential of betulin as a multitarget compound
Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing
properties. Despite having a wide range of pharmacological targets, no studies have …
properties. Despite having a wide range of pharmacological targets, no studies have …
Methods of betulin extraction from birch bark
OV Demets, AT Takibayeva, RZ Kassenov, MR Aliyeva - Molecules, 2022 - mdpi.com
Betulin is the most popular of the known triterpenoids of the lupan series. It has valuable
pharmacological properties. It exhibits antibacterial, antiviral, antitumor, hypolipidemic and …
pharmacological properties. It exhibits antibacterial, antiviral, antitumor, hypolipidemic and …
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research
J Hodon, L Borkova, J Pokorny, A Kazakova… - European journal of …, 2019 - Elsevier
Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …
Attenuation of quorum sensing controlled virulence factors and biofilm formation in Pseudomonas aeruginosa by pentacyclic triterpenes, betulin and betulinic acid
The production of virulence determinants and biofilm formation in numerous pathogens is
regulated by the cell-density-dependent phenomenon, Quorum sensing (QS). The QS …
regulated by the cell-density-dependent phenomenon, Quorum sensing (QS). The QS …
Pentacyclic triterpenoid phytochemicals with anticancer activity: Updated studies on mechanisms and targeted delivery
Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting
properties and pharmacological effects, with some representatives, such as betulinic acid …
properties and pharmacological effects, with some representatives, such as betulinic acid …
Methods of analysis and identification of betulin and its derivatives
AT Takibayeva, GK Zhumabayeva, AA Bakibaev… - Molecules, 2023 - mdpi.com
This scientific work presents practical and theoretical material on the methods of analysis
and identification of betulin and its key derivatives. The properties of betulin and its …
and identification of betulin and its key derivatives. The properties of betulin and its …
Betulonic acid derivatives interfering with human coronavirus 229E replication via the nsp15 endoribonuclease
A Stevaert, B Krasniqi, B Van Loy… - Journal of medicinal …, 2021 - ACS Publications
To develop antiviral therapeutics against human coronavirus (HCoV) infections, suitable
coronavirus drug targets and corresponding lead molecules must be urgently identified …
coronavirus drug targets and corresponding lead molecules must be urgently identified …