Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

The Bacteroides fragilis (B. fragilis) produce biofilm for colonisation in the intestinal tract can
cause a series of inflammatory reactions due to B. fragilis toxin (BFT) which can lead to …

Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …

Abstract Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc
and calcium endopeptidases. It can degrade a variety of extracellular matrix substrates and …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …

Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …