Novel mechanisms and functions of complement
Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
[HTML][HTML] The challenges and promise of complement therapeutics for ocular diseases
Ocular inflammation is a defining feature of sight threating diseases and its dysregulation
can catalyze and or propagate ocular neurodegenerative maladies such as age-related …
can catalyze and or propagate ocular neurodegenerative maladies such as age-related …
C3‐dependent effector functions of complement
A Zarantonello, M Revel, A Grunenwald… - Immunological …, 2023 - Wiley Online Library
C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …
functions through different binding sites and their corresponding receptors. We will introduce …
[HTML][HTML] Complement component C3: a structural perspective and potential therapeutic implications
As the most abundant component of the complement system, C3 and its proteolytic
derivatives serve essential roles in the function of all three complement pathways. Central to …
derivatives serve essential roles in the function of all three complement pathways. Central to …
Targeting complement components C3 and C5 for the retina: key concepts and lingering questions
Age-related macular degeneration (AMD) remains a major cause of legal blindness, and
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …
Functional characterization of 105 factor H variants associated with aHUS: lessons for variant classification
H Martín Merinero, Y Zhang, E Arjona… - Blood, The Journal …, 2021 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a life-threatening thrombotic microangiopathy
that can progress, when untreated, to end-stage renal disease. Most frequently, aHUS is …
that can progress, when untreated, to end-stage renal disease. Most frequently, aHUS is …
[HTML][HTML] Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
With the addition of the compstatin-based complement C3 inhibitor pegcetacoplan, another
class of complement targeted therapeutics have recently been approved. Moreover …
class of complement targeted therapeutics have recently been approved. Moreover …
[HTML][HTML] Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor
OJS Macleod, AD Cook, H Webb, M Crow… - Nature …, 2022 - nature.com
African trypanosomes are extracellular pathogens of mammals and are exposed to the
adaptive and innate immune systems. Trypanosomes evade the adaptive immune response …
adaptive and innate immune systems. Trypanosomes evade the adaptive immune response …
[PDF][PDF] Structural analysis of glycoproteins: building N-linked glycans with Coot
Coot is a graphics application that is used to build or manipulate macromolecular models; its
particular forte is manipulation of the model at the residue level. The model-building tools of …
particular forte is manipulation of the model at the residue level. The model-building tools of …
Sialylation acts as a checkpoint for innate immune responses in the central nervous system
Sialic acids are monosaccharides that normally terminate the glycan chains of cell surface
glyco‐proteins and‐lipids in mammals, and are highly enriched in the central nervous tissue …
glyco‐proteins and‐lipids in mammals, and are highly enriched in the central nervous tissue …