Cell division facilitated by a contractile ring is an almost universal feature across all
branches of cellular life, with the notable exception of higher plants. In all organisms that use …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

Cytokinesis, the final step of cell division, is a great example of robust cell shape regulation.
A wide variety of cells ranging from the unicellular Dictyostelium to human cells in tissues …

Complex behaviors are typically associated with animals, but the capacity to integrate
information and function as a coordinated individual is also a ubiquitous but poorly …

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical
changes in the cancer cell and its microenvironment. Cells with metastatic potential are often …

Cell-shape changes associated with processes like cytokinesis and motility proceed on
several-second timescales but are derived from molecular events, including protein-protein …

Cytokinesis occurs through the coordinated action of several biochemically-mediated
stresses acting on the cytoskeleton. Here, we develop a computational model of cellular …

The Hippo pathway effector Yes-associated protein (YAP) regulates liver size by promoting
cell proliferation and inhibiting apoptosis. However, recent in vivo studies suggest that YAP …

Cytokinesis is the step of the cell cycle in which the cell must faithfully separate the
chromosomes and cytoplasm, yielding two daughter cells. The assembly and contraction of …

Cells have evolved sophisticated systems that integrate internal and external inputs to
coordinate cell shape changes during processes, such as development, cell identity …