Impaired autonomic nervous system-microbiome circuit in hypertension: a premise for hypertension therapy

J Zubcevic, EM Richards, T Yang, S Kim… - Circulation …, 2019 - Am Heart Assoc
Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

S Gambaryan, D Tsikas - Amino acids, 2015 - Springer
Abstract The NO/sGC/cGMP/PKG system is one of the most powerful mechanisms
responsible for platelet inhibition. In numerous publications, expression of functional NO …

Hypertension associated with hyperlipidemia induced different microRNA expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of …

N Alexandru, A Constantin, M Nemecz… - Frontiers in …, 2019 - frontiersin.org
Aim: The aim of this study was to analyze the expressed profiles of miRNAs in plasma,
platelets, and platelet-derived microvesicles (PMVs) obtained from experimental induced …

[HTML][HTML] Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan

A Georgescu, N Alexandru, E Andrei, I Titorencu… - Journal of Thrombosis …, 2012 - Elsevier
Aims: This study aimed to (i) employ our newly designed model, the hypertensive–
hypercholesterolemic hamster (HH), in order to find out whether a correlation exists between …

Platelet dysfunction in vascular pathologies and how can it be treated

N Alexandru, D Popov, A Georgescu - Thrombosis research, 2012 - Elsevier
Cardiovascular diseases are one of the leading causes of morbidity and mortality in
industrialized countries, and although many processes play a role in the development of …

Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development

A Georgescu, N Alexandru, E Andrei… - Biology of the …, 2016 - Wiley Online Library
Background Information Atherosclerosis is an inflammatory disease, in which risk factors
such as hyperlipidemia and hypertension affect the arterial endothelium, resulting in …

Microarray truths and consequences

R Sasik, CH Woelk, J Corbeil - Journal of molecular …, 2004 - jme.bioscientifica.com
Dear Readers, Having served as Editor-in-Chief of Journal of Molecular Endocrinology for
seven years, I would like to take this opportunity to thank all those who have contributed to …

Cilostazol exerts antiplatelet and anti‐inflammatory effects through AMPK activation and NF‐kB inhibition on hypercholesterolemic rats

NAV da Motta, FCF de Brito - Fundamental & clinical …, 2016 - Wiley Online Library
This work presents a model of rats fed a high‐cholesterol diet, receiving a long‐term oral
administration of cilostazol, a PDE 3‐inhibitor. The aim of this study was to evaluate the …

Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis: Role of transplanted endothelial progenitor cells and platelet …

N Alexandru, E Andrei, E Dragan… - Biology of the …, 2015 - Wiley Online Library
Background information Recent studies suggest that endothelial progenitor cells (EPCs) and
platelets have an important role in repair following vascular injury. Although evidence …

[HTML][HTML] Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin–Mediated interaction of tumor cells with platelets and …

H Amano, Y Ito, F Ogawa, K Eshima, T Suzuki… - The American journal of …, 2013 - Elsevier
Angiotensin II is involved in tumor growth; however, the precise mechanism is not known.
Platelets also contribute to tumor growth, and angiotensin II type 1 receptor (AT1) is …