How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD

T Jovanovic, KJ Ressler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Exposure to traumatic events that produce extreme fear and horror is all too common in both
military and civilian populations, but not all individuals develop posttraumatic stress disorder …

A memory-based model of posttraumatic stress disorder: evaluating basic assumptions underlying the PTSD diagnosis.

DC Rubin, D Berntsen, MK Bohni - Psychological review, 2008 - psycnet.apa.org
In the mnemonic model of posttraumatic stress disorder (PTSD), the current memory of a
negative event, not the event itself, determines symptoms. The model is an alternative to the …

Large soluble oligomers of amyloid β-protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate

T Yang, S Li, H Xu, DM Walsh… - Journal of …, 2017 - Soc Neuroscience
Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …

Pilot study of secondary prevention of posttraumatic stress disorder with propranolol

RK Pitman, KM Sanders, RM Zusman, AR Healy… - Biological …, 2002 - Elsevier
Background: Preclinical considerations suggest that treatment with a β-adrenergic blocker
following an acute psychologically traumatic event may reduce subsequent posttraumatic …

Stress and memory: behavioral effects and neurobiological mechanisms

C Sandi, MT Pinelo-Nava - Neural plasticity, 2007 - Wiley Online Library
Stress is a potent modulator of learning and memory processes. Although there have been a
few attempts in the literature to explain the diversity of effects (including facilitating …

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

D Tse, L Privitera, AC Norton… - Proceedings of the …, 2023 - National Acad Sciences
Memory formation is typically divided into phases associated with encoding, storage,
consolidation, and retrieval. The neural determinants of these phases are thought to differ …

Propranolol's effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis

MH Lonergan, LA Olivera-Figueroa, RK Pitman… - Journal of Psychiatry and …, 2013 - jpn.ca
Background: Considering the pivotal role of negative emotional experiences in the
development and persistence of mental disorders, interfering with the consolidation …

Emotion enhances remembrance of neutral events past

AK Anderson, PE Wais… - Proceedings of the …, 2006 - National Acad Sciences
Emotional events are bestowed with special prominence in memory. This may reflect greater
attention oriented to these events during encoding, and/or enhancement of memory …

Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer's disease

YJ Cheng, CH Lin, HY Lane - International Journal of Molecular Sciences, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …

[HTML][HTML] Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers

S Li, M Jin, D Zhang, T Yang, T Koeglsperger, H Fu… - Neuron, 2013 - cell.com
A central question about human brain aging is whether cognitive enrichment slows the
development of Alzheimer changes. Here, we show that prolonged exposure to an enriched …