How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD
T Jovanovic, KJ Ressler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Exposure to traumatic events that produce extreme fear and horror is all too common in both
military and civilian populations, but not all individuals develop posttraumatic stress disorder …
military and civilian populations, but not all individuals develop posttraumatic stress disorder …
A memory-based model of posttraumatic stress disorder: evaluating basic assumptions underlying the PTSD diagnosis.
DC Rubin, D Berntsen, MK Bohni - Psychological review, 2008 - psycnet.apa.org
In the mnemonic model of posttraumatic stress disorder (PTSD), the current memory of a
negative event, not the event itself, determines symptoms. The model is an alternative to the …
negative event, not the event itself, determines symptoms. The model is an alternative to the …
Large soluble oligomers of amyloid β-protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate
Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …
Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
RK Pitman, KM Sanders, RM Zusman, AR Healy… - Biological …, 2002 - Elsevier
Background: Preclinical considerations suggest that treatment with a β-adrenergic blocker
following an acute psychologically traumatic event may reduce subsequent posttraumatic …
following an acute psychologically traumatic event may reduce subsequent posttraumatic …
Stress and memory: behavioral effects and neurobiological mechanisms
C Sandi, MT Pinelo-Nava - Neural plasticity, 2007 - Wiley Online Library
Stress is a potent modulator of learning and memory processes. Although there have been a
few attempts in the literature to explain the diversity of effects (including facilitating …
few attempts in the literature to explain the diversity of effects (including facilitating …
Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats
D Tse, L Privitera, AC Norton… - Proceedings of the …, 2023 - National Acad Sciences
Memory formation is typically divided into phases associated with encoding, storage,
consolidation, and retrieval. The neural determinants of these phases are thought to differ …
consolidation, and retrieval. The neural determinants of these phases are thought to differ …
Propranolol's effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis
MH Lonergan, LA Olivera-Figueroa, RK Pitman… - Journal of Psychiatry and …, 2013 - jpn.ca
Background: Considering the pivotal role of negative emotional experiences in the
development and persistence of mental disorders, interfering with the consolidation …
development and persistence of mental disorders, interfering with the consolidation …
Emotion enhances remembrance of neutral events past
AK Anderson, PE Wais… - Proceedings of the …, 2006 - National Acad Sciences
Emotional events are bestowed with special prominence in memory. This may reflect greater
attention oriented to these events during encoding, and/or enhancement of memory …
attention oriented to these events during encoding, and/or enhancement of memory …
Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer's disease
Alzheimer's disease (AD), the most common cause of dementia, is a progressive
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …
neurodegenerative disease. The number of AD cases has been rapidly growing worldwide …
[HTML][HTML] Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers
A central question about human brain aging is whether cognitive enrichment slows the
development of Alzheimer changes. Here, we show that prolonged exposure to an enriched …
development of Alzheimer changes. Here, we show that prolonged exposure to an enriched …