Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Spices for prevention and treatment of cancers

J Zheng, Y Zhou, Y Li, DP Xu, S Li, HB Li - Nutrients, 2016 - mdpi.com
Spices have been widely used as food flavorings and folk medicines for thousands of years.
Numerous studies have documented the antioxidant, anti-inflammatory and …

[HTML][HTML] Thymoquinone: A novel strategy to combat cancer: A review

M Imran, A Rauf, IA Khan, M Shahbaz… - Biomedicine & …, 2018 - Elsevier
The higher consumption of fruit, herbs, spices, and vegetables is well known and practical
strategy to cure human cancers owing to their presence of bioactive compounds. Among …

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

M Buccarelli, M Marconi, S Pacioni, I De Pascalis… - Cell death & …, 2018 - nature.com
The role of autophagy in cancer onset and progression appears still controversial. On one
hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on …

[HTML][HTML] Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

MA Khan, M Tania, S Fu, J Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this
review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of …

[HTML][HTML] Thymoquinone: an emerging natural drug with a wide range of medical applications

M Khader, PM Eckl - Iranian journal of basic medical sciences, 2014 - ncbi.nlm.nih.gov
Nigella sativa has attracted healers in ancient civilizations and researchers in recent times.
Traditionally, it has been used in different forms to treat many diseases including asthma …

Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

U Fatima, S Roy, S Ahmad, S Ali, WM Elkady… - Frontiers in …, 2022 - frontiersin.org
Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in
combination with other herbs, as a memory and learning enhancer, sedative, and anti …

Modulating autophagy in cancer therapy: advancements and challenges for cancer cell death sensitization

P Bhat, J Kriel, BS Priya, NS Shivananju… - Biochemical …, 2018 - Elsevier
Autophagy is a major protein degradation pathway capable of upholding cellular
metabolism under nutrient limiting conditions, making it a valuable resource to highly …

The role of cysteine cathepsins in cancer progression and drug resistance

M Rudzińska, A Parodi, SM Soond, AZ Vinarov… - International journal of …, 2019 - mdpi.com
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their
expression is misregulated in a wide variety of tumors, and ample data prove their …