Schistosomiasis, a major neglected tropical disease, affects more than 250 million people
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Introduction Helminths are parasitic worms that infect millions of people worldwide and
secrete a variety of excretory-secretory products (ESPs), including proteins, peptides, and …

Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

Tissue fibrosis underlies the majority of human mortality to date with close to half of all
reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and …

Schistosomes are human pathogens causing the neglected tropical disease
schistosomiasis, which occurs worldwide in (sub-) tropical regions. This infectious disease is …

Schistosomiasis is considered a serious public health problem in 78 countries and territories
located in Africa, Asia and America and it is estimated in more than 249 million people …

Praziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of
schistosomiasis. Its high hydrophobic character and its low water solubility are the main …

Spatial metabolomics is a new field that has risen rapidly in recent years, using mass
spectrometry imaging (MSI) technology, such as matrix-assisted laser desorption ionization …

Schistosomiasis is a neglected tropical disease of clinical significance that, despite years of
research, still requires an effective vaccine and improved diagnostics for surveillance …