Historically, the human brain has been conceptually segregated from the periphery and
further dichotomized into gray matter (GM) and white matter (WM) based on the whitish …

Several lines of evidence suggest that the normal integration of cerebral communication
may be compromised in schizophrenia, with white matter (WM) abnormalities being integral …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Healthy nodes of Ranvier are crucial for action potential propagation along myelinated
axons, both in the central and in the peripheral nervous system. Surprisingly, the node of …

Altered glial structure and function is implicated in several major mental illnesses and
increasing evidence specifically links changes in oligodendrocytes with disrupted mood …

AnkyrinG, encoded by the ANK3 gene, is involved in neuronal development and signaling. It
has previously been implicated in bipolar disorder and schizophrenia by association …

Oligodendrocytes are the myelinating cells of the central nervous system that constitute
about 5 to 10% of the total glial population. These cells are responsible for myelin sheath …

Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …

The powerful genome-wide association studies (GWAS) revealed common mutations that
increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority …

BACKGROUND: Elevated rate of aging-related biological and functional decline, termed
“accelerated aging,” is reported in patients with schizophrenia (SCZ) and major depressive …