The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …

The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …

Cell spreading, adhesion and remodelling of the extracellular matrix (ECM) involve bi-
directional signalling and physical linkages between the ECM, integrins and the cell …

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction
can be viewed as a cyclical liaison, which develops again and again at new adhesion sites …

Membrane phosphoinositides control a variety of cellular processes through the recruitment
and/or regulation of cytosolic proteins,,,. One mechanism ensuring spatial specificity in …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …