Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

Lactate can be produced by many gut bacteria, but in adults its accumulation in the colon is
often an indicator of microbiota perturbation. Using continuous culture anaerobic fermentor …

Most fungal species are harmless to humans and some exist as commensals on
mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life …

SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …

Opportunistic infections by environmental fungi are a growing clinical problem, driven by an
increasing population of people with immunocompromising conditions. Spores of the …

The phagocytic cells of the innate immune system are an essential first line of antimicrobial
defense, and yet Candida albicans, one of the most problematic fungal pathogens, is …

Despite the importance of fungal cell walls as the principle determinant of fungal
morphology and the defining element determining fungal interactions with other cells, few …

Organisms must adapt to changes in oxygen tension if they are to exploit the energetic
benefits of reducing oxygen while minimizing the potentially damaging effects of oxidation …

Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …

The cell wall provides a major physical interface between fungal pathogens and their
mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival …