Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

HW Barkema, K Orsel, SS Nielsen… - Transboundary and …, 2018 - Wiley Online Library
In the last decades, many regional and country‐wide control programmes for Johne's
disease (JD) were developed due to associated economic losses, or because of a possible …

Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne's Disease

G Rathnaiah, DK Zinniel, JP Bannantine… - Frontiers in veterinary …, 2017 - frontiersin.org
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's
disease in ruminants causing chronic diarrhea, malnutrition, and muscular wasting …

Vaccines for immune tolerance against autoimmune disease

A Kim, F Xie, OA Abed, JJ Moon - Advanced drug delivery reviews, 2023 - Elsevier
The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …

Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo …

GS Abdellrazeq, LM Fry, MM Elnaggar, JP Bannantine… - Vaccine, 2020 - Elsevier
Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria,
develop following stimulation of monocyte-depleted peripheral blood mononuclear cells …

A rational framework for evaluating the next generation of vaccines against Mycobacterium avium subspecies paratuberculosis

JP Bannantine, ME Hines, LE Bermudez… - Frontiers in cellular …, 2014 - frontiersin.org
Since the early 1980s, several investigations have focused on developing a vaccine against
Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne's …

A protective vaccine against Johne's disease in cattle

Y Phanse, CW Wu, AJ Venturino, C Hansen, K Nelson… - Microorganisms, 2020 - mdpi.com
Johne's disease (JD) caused by Mycobacterium avium subsp. paratuberculosis (M.
paratuberculosis) is a chronic infection characterized by the development of granulomatous …

Evaluation of a Mycobacterium avium subsp. paratuberculosis leuD Mutant as a Vaccine Candidate against Challenge in a Caprine Model

SM Faisal, JW Chen, F Yan, TT Chen… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Johne's disease (JD) is prevalent worldwide and has a significant impact on the global
agricultural economy. In the present study, we evaluated the protective efficacy of a leuD (Δ …

Phenotype and Function of CD209+ Bovine Blood Dendritic Cells, Monocyte-Derived-Dendritic Cells and Monocyte-Derived Macrophages

KT Park, MM ElNaggar, GS Abdellrazeq… - PloS one, 2016 - journals.plos.org
Phylogenic comparisons of the mononuclear phagocyte system (MPS) of humans and mice
demonstrate phenotypic divergence of dendritic cell (DC) subsets that play similar roles in …

Development of vaccines to Mycobacterium avium subsp. paratuberculosis infection

HT Park, HS Yoo - Clinical and experimental vaccine …, 2016 - synapse.koreamed.org
Johne's disease or paratuberculosis is a chronic debilitating disease in ruminants caused by
Mycobacterium avium subsp. paratuberculosis (MAP). The disease causes significant …

Superior protection from live-attenuated vaccines directed against Johne's disease

DC Shippy, JJ Lemke, A Berry, K Nelson… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the etiological agent
of Johne's disease in ruminants. Johne's disease is an important enteric infection causing …