Chimeric antigen receptor T-cell therapies for lymphoma

JN Brudno, JN Kochenderfer - Nature reviews Clinical oncology, 2018 - nature.com
New therapies are needed for patients with Hodgkin or non-Hodgkin lymphomas that are
resistant to standard therapies. Indeed, unresponsiveness to standard chemotherapy and …

Non-hodgkin lymphoma

KR Shankland, JO Armitage, BW Hancock - The Lancet, 2012 - thelancet.com
Lymphomas are solid tumours of the immune system. Hodgkin's lymphoma accounts for
about 10% of all lymphomas, and the remaining 90% are referred to as non-Hodgkin …

Anti-CD30 CAR-T cell therapy in relapsed and refractory Hodgkin lymphoma

CA Ramos, NS Grover, AW Beaven, PD Lulla… - Journal of clinical …, 2020 - ascopubs.org
PURPOSE Chimeric antigen receptor (CAR) T-cell therapy of B-cell malignancies has
proved to be effective. We show how the same approach of CAR T cells specific for CD30 …

[HTML][HTML] The application of CAR-T cell therapy in hematological malignancies: advantages and challenges

Z Zhao, Y Chen, NM Francisco, Y Zhang… - Acta Pharmaceutica Sinica …, 2018 - Elsevier
Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy
where T lymphocytes are engineered with synthetic receptors known as chimeric antigen …

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.

NL Harris, ES Jaffe, H Stein, PM Banks, JKC Chan… - blood, 1994 - europepmc.org
A comment on this article appears in" Algorithm for immunophenotyping of low-grade B
lymphomas." Blood. 1996 Sep 15; 88 (6): 2361-2. A comment on this article appears in" …

Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions

CA Van der Weyden, SA Pileri, AL Feldman… - Blood cancer …, 2017 - nature.com
CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically
expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma …

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

KJ Hamblett, PD Senter, DF Chace, MMC Sun… - Clinical cancer …, 2004 - AACR
Purpose: An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE)
conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug moieties …

ALK anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified …

KJ Savage, NL Harris, JM Vose, F Ullrich… - Blood, The Journal …, 2008 - ashpublications.org
Abstract The International Peripheral T-Cell Lymphoma Project is a collaborative effort
designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell …

The anaplastic lymphoma kinase in the pathogenesis of cancer

R Chiarle, C Voena, C Ambrogio, R Piva… - Nature Reviews …, 2008 - nature.com
Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

The biology and management of systemic anaplastic large cell lymphoma

G Hapgood, KJ Savage - Blood, The Journal of the American …, 2015 - ashpublications.org
Systemic anaplastic large cell lymphoma (ALCL) is an aggressive CD30+ non-Hodgkin
lymphoma. Anaplastic lymphoma kinase–positive (ALK+) ALCL is associated with the NPM …