Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential

A Singh, L Singh - Pharmacological Reports, 2024 - Springer
Sesquiterpenes are a class of organic compounds found in plants, fungi, and some insects.
They are characterized by the presence of three isoprene units, resulting in a molecular …

Farnesol exerts protective effects against chronic sleep deprivation‐induced cognitive impairment via activation SIRT1/Nrf2 pathway in the hippocampi of adult mice

Y Li, Z Xie, X Luo, X Wang, Y Wang… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Sleep deprivation (SD) negatively affects all aspects of health, with one serious
consequence being impaired cognition. Farnesol (FOL) is a sesquiterpene synthesized by …

Christensenella strain resources, genomic/metabolomic profiling, and association with host at species level

XW Sun, HJ Huang, XM Wang, RQ Wei, HY Niu… - Gut …, 2024 - Taylor & Francis
The gut commensal bacteria Christensenellaceae species are negatively associated with
many metabolic diseases, and have been seen as promising next-generation probiotics …

Vasorelaxant effect of (E, E)-farnesol in human umbilical vein ex vivo assays

PR Batista, A de Alencar Silva… - Chemico-Biological …, 2023 - Elsevier
Abstract (E, E)-farnesol is a sesquiterpene acyclic alcohol produced by bacteria, protozoa,
fungi, plants, and animals. The literature describes its applications in food, pharmaceutical …

Investigation of mechanisms of action involved in the antidepressant-like effect of Trans, trans-farnesol in mice

G de Araújo Delmondes, MJP Lopes… - Chemico-Biological …, 2023 - Elsevier
This study aimed to investigate, through in vivo and biochemical methodologies, the effect of
trans, trans-farnesol (12.5, 25, 50 or 100 mg/kg, po) acute administration, adopting different …

Neuroprotective mechanism of trans, trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer's pathology

M Kadian, N Saini, A Khera, A Kumar - Inflammopharmacology, 2024 - Springer
Background Alzheimer's disease (AD) is a prominent cause of dementia, resulting in
neurodegeneration and memory impairment. This condition imposes a considerable public …