Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

The mucolytic human gut microbiota specialist Akkermansia muciniphila is proposed to
boost mucin-secretion by the host, thereby being a key player in mucus turnover. Mucin …

The involvement of host immunity in the gut microbiota-mediated colonization resistance to
Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that …

This protocol shows how to obtain a detailed glycan compositional and structural profile from
purified glycoproteins or protein mixtures, and it can be used to distinguish different isobaric …

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF
transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not …

Background The MUC2 mucin organizes the two mucus layers in the colon. This mucin
carries a large number of O-glycans that are assumed to be attachment sites for the …

Background Protection of the large intestine with its enormous amount of commensal
bacteria is a challenge that became easier to understand when we recently could describe …

The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac
muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix …