Bisphosphonates are a unique class of drugs. As a family, they are characterized
pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically …

Bisphosphonates suppress osteoclast-mediated bone resorption and are widely used in the
management of osteoporosis. Daily oral administration of alendronic acid and risedronic …

Bisphosphonates are well-known inhibitors of osteoclastic bone resorption, but recent
clinical reports support the possibility of direct or indirect antitumor effects by these …

PURPOSE: Bisphosphonates (BPs) are a widely used class of drugs that are effective in the
treatment and prevention of osteoporosis, hypercalcemia of malignancy, and bone …

Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption
is in excess. However, the mechanism of bisphosphonate action on bone is not fully …

The pharmacokinetics, pharmacodynamics, and safety of zoledronic acid (Zometa®), a new‐
generation bisphosphonate, were evaluated in 36 patients with cancer and bone …

The presence of skeletal metastases in patients suffering from cancer leads to a variety of
clinical complications. Bisphosphonates are a class of drugs with a potent bone resorption …

Bisphosphonates are widely used in the treatment of diseases involving excessive bone
resorption, such as osteoporosis, cancer-associated bone disease, and Paget's disease of …

Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal
complications associated with metastastic bone disease, Paget's disease, and osteoporosis …

The acute phase response is the major adverse effect of intravenously administered N‐BPs.
In this study we show that N‐BPs cause γ, δ‐T‐cell activation and proliferation in vitro by an …