Importance Epilepsy affects approximately 65 million people worldwide. Persistent seizures
are associated with a 20% to 40% risk of bodily injuries (eg, fractures, burns, concussions) …

Drug resistant epilepsy (DRE) is defined as the persistence of seizures despite at least two
syndrome-adapted antiseizure drugs (ASD) used at efficacious daily dose. Despite the …

Abstract In 2017, the International League Against Epilepsy (ILAE) Classification of
Epilepsies described the “genetic generalized epilepsies”(GGEs), which contained the …

Objective: To assess efficacy and safety of adjunctive perampanel in patients with drug-
resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized …

Background and purpose Juvenile myoclonic epilepsy (JME) is a common epilepsy
syndrome for which treatment response is generally assumed to be good. We aimed to …

The prevailing understanding of generalized epilepsy is shaped by the traditional definition
that “the responsible neuronal discharge takes place, if not throughout the entire grey matter …

Epileptic seizures are generally unpredictable and arise spontaneously. Patients often
report non-specific triggers such as stress or sleep deprivation, but only rarely do seizures …

Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …

In consequence of newer research juvenile myoclonic epilepsy (JME) is no longer seen as a
homogeneous disease. The causes of the existing variance are only partially known yet. We …

Purpose Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been
recognized as a common epileptic syndrome worldwide. Methods We reviewed a series of …