Limbal stem cells constitute an important cell population required for regeneration of the
corneal epithelium. If insults to limbal stem cells or their niche are sufficiently severe, a …

Limbal function is a key determinant of corneal epithelial integrity. Lineage tracing studies in
mice have highlighted that the centripetal movement of epithelial progenitors from the limbus …

A functional limbal epithelial stem cells (LSC) niche is a vital element in the regular renewal
of the corneal epithelium by LSCs and maintenance of good vision. However, little is known …

Limbal stem cell deficiency and corneal disorders are among the top global threats for
human vision. Emerging therapies that integrate stem cell transplantation with engineered …

Background Differentiation of functional limbal stem cells (LSCs) from human pluripotent
stem cells (hPSCs) is an important objective which can provide novel treatment solutions for …

Dry eye disease (DED) affects a substantial worldwide population with increasing frequency.
Current single-targeting DED management is severely hindered by the existence of an …

Congenital aniridia is a rare, pan-ocular disease causing severe sight loss, with only
symptomatic intervention offered to patients. Approximately 40% of aniridia patients present …

Deficiency and dysfunction of corneal cells leads to the blindness observed in corneal
diseases such as limbal stem cell deficiency (LSCD) and bullous keratopathy. Regenerative …

Deficiency of corneal epithelium causes vision impairment or blindness in severe cases.
Transplantation of corneal epithelial cells is an effective treatment but the availability of the …

Corneal disease remains to be one of the leading causes of blindness in the world and
limbal stem cell (LSC) therapy is a promising therapy for LSC deficiency, which is associated …