Molecular mechanisms of acrolein toxicity: relevance to human disease
A Moghe, S Ghare, B Lamoreau… - Toxicological …, 2015 - academic.oup.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized …
and its potential as a serious environmental health threat is beginning to be recognized …
Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases
Traumatic brain injury is among the most common causes of death and disability in youth
and young adults. In addition to the acute risk of morbidity with moderate to severe injuries …
and young adults. In addition to the acute risk of morbidity with moderate to severe injuries …
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke
Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has
been paid to the reduced harm potential of alternative nicotine-containing inhalable …
been paid to the reduced harm potential of alternative nicotine-containing inhalable …
[HTML][HTML] Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice
WY Chen, J Zhang, S Ghare, S Barve… - Cellular and molecular …, 2016 - Elsevier
Background & Aims Alcoholic liver disease (ALD) remains a major cause of morbidity and
mortality, with no Food and Drug Administration–approved therapy. Chronic alcohol …
mortality, with no Food and Drug Administration–approved therapy. Chronic alcohol …
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury
Currently there are no effective therapies available for the excruciating neuropathic pain that
develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the …
develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the …
Neuroprotective role of hydralazine in rat spinal cord injury‐attenuation of acrolein‐mediated damage
Acrolein, an α, β‐unsaturated aldehyde and a reactive product of lipid peroxidation, has
been suggested as a key factor in neural post‐traumatic secondary injury in spinal cord …
been suggested as a key factor in neural post‐traumatic secondary injury in spinal cord …
[HTML][HTML] Activation of cellular signalling pathways and apoptosis by the aldehyde acrolein–A major environmental hazard
DA Averill-Bates, A Tanel - Redox Biochemistry and Chemistry, 2024 - Elsevier
Interest in the molecular actions of acrolein has increased in light of growing knowledge that
implicates this reactive aldehyde in a wide range of pathophysiologies including …
implicates this reactive aldehyde in a wide range of pathophysiologies including …
Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration
Survivors of blast-induced traumatic brain injury (bTBI) have increased susceptibility to
Parkinson's disease (PD), characterized by α-synuclein aggregation and the progressive …
Parkinson's disease (PD), characterized by α-synuclein aggregation and the progressive …
Alterations in acrolein metabolism contribute to Alzheimer's disease
Alzheimer's disease (AD) is a detrimental neurodegenerative disease, and early diagnosis
appears to be the key to successful treatment. Acrolein, a byproduct of lipid peroxidation …
appears to be the key to successful treatment. Acrolein, a byproduct of lipid peroxidation …
Acrolein contributes to TRPA 1 up‐regulation in peripheral and central sensory hypersensitivity following spinal cord injury
Acrolein, an endogenous aldehyde, has been shown to be involved in sensory
hypersensitivity after rat spinal cord injury (SCI), for which the pathogenesis is unclear …
hypersensitivity after rat spinal cord injury (SCI), for which the pathogenesis is unclear …