The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China.
N6− methyladenosine (m6A) plays an important role in posttranscriptional gene regulation …

Human exonuclease 1 (EXO1), a 5′→ 3′ exonuclease, contributes to the regulation of the
cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair …

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen
(PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to …

Accurate diagnosis and targeted therapy are essential to precision theranostics. However,
nonspecific response of theranostic agents in healthy tissues impedes their practical …

Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and
avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and …

Flap endonuclease 1 (FEN1) participates in both DNA replication and repair to maintain the
stability and integrity of the genome. As a potential tumor marker, detecting FEN1 activity …

Overexpression of Flap endonuclease 1 (FEN1) has been previously implicated in
hepatocellular carcinoma (HCC), while its expression features and mechanisms remain …

Loss of BRCA2 (br east ca ncer 2) is lethal for normal cells. Yet it remains poorly understood
how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the …

During lagging strand synthesis, DNA Ligase 1 (Lig1) cooperates with the sliding clamp
PCNA to seal the nicks between Okazaki fragments generated by Pol δ and Flap …