Some of the most prominent and promising catalysts in organic synthesis for the requisite
construction of C–C and C–N bonds are palladium (Pd) catalysts, which play a pivotal role in …

Conspectus The structural complexity of pharmaceuticals presents a significant challenge to
modern catalysis. Many published methods that work well on simple substrates often fail …

This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals |
Organic Process Research & Development ACS ACS Publications C&EN CAS Find my …

This is an overview of successes in the realm of catalytic homogeneous asymmetric
hydrogenation of substrates primarily of interest in the synthesis of pharmaceuticals in order …

Photoredox catalysis has emerged as a powerful tool for the synthetic chemist to access
challenging targets and to generate new structural complexity. This review focuses on the …

Amide couplings are one of, if not the most common chemical reactions performed in the
pharmaceutical industry. Many amide bonds are generated with the help of highly active …

Here we report an asymmetric formal nucleophilic o-cresolylation reaction with the Morita–
Baylis–Hillman (MBH) carbonates from 2-cyclohexanones and diverse aldehydes under …

In this account, we describe the design, synthesis and applications of tethered versions of
the Ru (II)/N‐tosyl‐1, 2‐diphenylethylene‐1, 2‐diamine (TsDPEN) class of catalyst that are …

A highly effective hydroxylation reaction of aryl halides with water under synergistic
organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols …