Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
[HTML][HTML] Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …
single-cell technologies have revealed that these reactive microglia were with high spatial …
[HTML][HTML] Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
The principal signals that drive memory and cognitive impairment in Alzheimer's disease
(AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN …
(AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN …
Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5× FAD mice
X Xie, G Ma, X Li, J Zhao, Z Zhao, J Zeng - Nature aging, 2023 - nature.com
Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …
trigger cellular innate immune response in a STING-dependent manner; however, it remains …
[HTML][HTML] Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2
JV Haure-Mirande, M Audrain, ME Ehrlich… - Molecular …, 2022 - Springer
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …
[HTML][HTML] The effects of microglia-associated neuroinflammation on Alzheimer's disease
C Wang, S Zong, X Cui, X Wang, S Wu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …
[HTML][HTML] Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
[HTML][HTML] Microglia-containing human brain organoids for the study of brain development and pathology
W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …
brain development and homeostasis. Increasing evidence has implicated microglia …
[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Staging of Alzheimer's disease: past, present, and future perspectives
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …
disease, the tail end of a pathophysiological process that lasts approximately two decades …