During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Background Cancer is one of the greatest public health challenges worldwide, and we still
lack complementary approaches to significantly enhance the efficacy of standard anticancer …

Pheochromocytoma and Paraganglioma Pheochromocytoma and paraganglioma are
related tumors that differ mainly in location; pheochromocytomas are adrenal, and …

As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Biochemistry textbooks and cell culture experiments seem to be telling us two different
things about the significance of external glutamine supply for mammalian cell growth and …