Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Computational approaches to therapeutic antibody design: established methods and emerging trends
Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
Elucidating how antigen exposure and selection shape the human antibody repertoire is
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
Analyzing immunoglobulin repertoires
N Chaudhary, DR Wesemann - Frontiers in immunology, 2018 - frontiersin.org
Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast
diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput …
diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput …
Molecular correlates of vaccine-induced protection against typhoid fever
H Zhu, I Chelysheva, DL Cross… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella
enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines …
enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines …
Biophysicochemical motifs in T-cell receptor sequences distinguish repertoires from tumor-infiltrating lymphocyte and adjacent healthy tissue
Immune repertoire deep sequencing allows comprehensive characterization of antigen
receptor–encoding genes in a lymphocyte population. We hypothesized that this method …
receptor–encoding genes in a lymphocyte population. We hypothesized that this method …
Advanced model systems and tools for basic and translational human immunology
There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …
study the immune system. We have learned much from genetically manipulated and inbred …