At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for
members of the transforming growth factor-β superfamily of proteins. A major role for …

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …

The developmental origins of health and disease theory is based on evidence that a
suboptimal environment during fetal and neonatal development can significantly impact the …

Since the early 1990s, several strains of genetically modified mice have been developed as
models for experimental atherosclerosis. Among the available models, the apolipoprotein E …

Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive
molecule involved in the regulation of many cellular processes. One of the most prominent …

Blood pressure is determined by cardiac output and peripheral vascular resistance. The L-
type voltage-gated Ca2+ (Cav1. 2) channel in small arteries and arterioles plays an …