Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …

Targeted protein degradation, with its rapid protein depletion kinetics, allows the
measurement of acute changes in the cell. The auxin-inducible degron (AID) system, rapidly …

The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin
modifications and three-dimensional genome architecture; however, causal links have not …

Abstract 53BP1 is a chromatin‐binding protein that promotes DNA double‐strand break
repair through the recruitment of downstream effectors including RIF1, shieldin, and CST …

RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing.
During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin …

B cell lymphopoiesis requires dynamic modulation of the B cell transcriptome for timely
coordination of somatic mutagenesis and DNA repair in progenitor B (pro-B) cells. Here, we …

We previously used a pulse-based in vitro assay to unveil targetable signalling pathways
associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et al., 2020) …

The organisation of chromatin is closely intertwined with biological activities of chromosome
domains, including transcription and DNA replication status. Scaffold-attachment factor A …

The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …

The cytolethal distending toxin (CDT) is produced by several Gram-negative pathogenic
bacteria. In addition to inflammation, experimental evidences are in favor of a protumoral …