The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Over the last decade, transcriptome studies of postmortem tissue from subjects with
schizophrenia revealed that synaptic, mitochondrial, immune system, gamma-aminobutyric …

Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …

Schizophrenia, a severe and debilitating disorder with a high social burden, affects 1% of
the adult world population. Available therapies are unable to treat all the symptoms, and …

We have seen an era of explosive progress in translating neurobiology into etiological
understanding of mental disorders for the past 10–15 years. The discovery of Disrupted-in …

Abstract Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it
predisposes individuals to a wide range of mental illnesses. Notably, a number of genes …

Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part
from abnormal communication within hippocampal–prefrontal circuits. While it has been …

Several recent research findings indicate that schizophrenia (SCZ) may begin with an
abnormal neuro-genesis from embryonic Neural Stem Cells (NSCs) and that this process …

Aberrant changes in gene function are believed to be involved in a wide spectrum of human
disease including behavioral, cognitive and neurodegenerative pathologies. Most of the …