The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune
responses and tolerance. DCs promote immune tolerance by participating in the negative …

l-arginine (l-Arg) deficiency results in decreased T-cell proliferation and impaired T-cell
function. Here we have found that l-Arg depletion inhibited expression of different membrane …

Autophagy regulates cell differentiation, proliferation, and survival in multiple cell types,
including cells of the immune system. In this study, we examined the effects of a disruption of …

Protocatechuic acid (PCA), a natural phenolic acid, is known for antioxidant, anti-
inflammatory, anti-apoptotic, and anti-fibrotic activities. However, the protective mechanisms …

Objective. Autophagy and long noncoding RNAs (lncRNAs) have been the focus of research
on the pathogenesis of melanoma. However, the autophagy network of lncRNAs in …

Quorum sensing (QS) was historically described as a mechanism by which bacteria detect
and optimize their population density via gene regulation based on dynamic environmental …

Purpose Starting in 2019, coronavirus disease 2019 (COVID-19) caused an epidemic that
was growing rapidly and has harmed millions of people globally. It has been demonstrated …

Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover,
changes in necrosis as a function of age have not been studied in human lymphocytes …

CD47 is known to play an important role in CD4+ T cell homeostasis. We recently reported a
reduction in mice deficient in the Cd47 gene (Cd47−/−) CD4+ T cell adhesion and …