[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
TRPA1 as a therapeutic target for nociceptive pain
D Souza Monteiro de Araujo, R Nassini… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
RG Pertwee - Current medicinal chemistry, 2010 - ingentaconnect.com
It is widely accepted that non-endogenous compounds that target CB1 and/or CB2 receptors
possess therapeutic potential for the clinical management of an ever growing number of …
possess therapeutic potential for the clinical management of an ever growing number of …
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control
BF Bessac, SE Jordt - Physiology, 2008 - journals.physiology.org
New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion
channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine …
channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine …
Trpa1
PM Zygmunt, ED Högestätt - … potential (TRP) cation channels: volume I, 2014 - Springer
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
TRPA1 agonists evoke coughing in guinea pig and human volunteers
Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a
general or respiratory physician. Treatment options are limited and one meta-analysis …
general or respiratory physician. Treatment options are limited and one meta-analysis …
Allyl isothiocyanate as a cancer chemopreventive phytochemical
Y Zhang - Molecular nutrition & food research, 2010 - Wiley Online Library
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, is widely
and often frequently consumed by humans. Besides antimicrobial activity against a wide …
and often frequently consumed by humans. Besides antimicrobial activity against a wide …
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
The transient receptor potential A1 (TRPA1) channel is the molecular target for
environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil …
environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil …
The G protein–coupled receptor–transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation
Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel
Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction
of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that …
of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that …