Background: Over the last 10 years, DNA microarrays have achieved a robust analytical
performance, enabling their use for analyzing the whole transcriptome or for screening …

Early diagnosis has been the'Achilles heel'of acute kidney injury (AKI) that has prevented
successful implementation of treatment strategies. To date, pharmacological intervention …

Interactions of proteins with low-molecular-weight ligands, such as metabolites, cofactors,
and allosteric regulators, are important determinants of metabolism, gene regulation, and …

Although many methods exist to study the recognition and signaling properties of proteins in
isolation, it remains a challenge to perform these investigations on a system-wide or …

Mapping of protein signaling networks within tumors can identify new targets for therapy and
provide a means to stratify patients for individualized therapy. Kinases are important drug …

A large number of biomarkers have been discovered over the past few years using
proteomics techniques. Unfortunately, most of them are neither specific nor sensitive enough …

Capturing quantitative proteomic information provides new insights for enhancing the
understanding of cancer biology. There have been several protein microarray formats, and …

Lysate microarrays (reverse-phase protein arrays) hold great promise as a tool for systems-
level investigations of signaling and multiplexed analyses of disease biomarkers. To date …

Understanding the factors that influence human health and cause diseases has always
been one of the major driving forces of biological research. With the spectacular progresses …

Intestinal ischemia/reperfusion (I/R) injury initiates a systemic inflammatory response
syndrome with a high associated mortality rate. Early diagnosis is essential for reducing …