“You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic

DKC Cooper, H Hara - EBioMedicine, 2021 - thelancet.com
Progress in life-supporting kidney transplantation in the genetically-engineered pig-to-
nonhuman primate model has been encouraging, with pig kidneys sometimes supporting …

Xenotransplantation: A historical–ethical account of viewpoints

D Rodger, DJ Hurst, DKC Cooper - Xenotransplantation, 2023 - Wiley Online Library
Formal clinical trials of pig‐to‐human organ transplant—known asxenotransplantation—may
begin this decade, with the first trials likely to consist of either adult renal transplants or …

Genetically engineered pig kidney transplantation in a brain‐dead human subject

DKC Cooper - Xenotransplantation, 2021 - Wiley Online Library
In September 2021, a kidney (with donor‐specific thymic tissue) from an α1, 3‐
galactosyltransferase gene‐knockout (GTKO) pig was transplanted into the groin (with …

Public attitudes to xenotransplantation: A national survey in the United States

LA Padilla, DJ Hurst, A Zink, B Parent… - American Journal of …, 2024 - Elsevier
Xenotransplantation (XTx) presents a potential clinical alternative to the shortage of human
organs for transplantation. Before clinical trials occur in the United States, public …

Update on the ethical, legal and technical challenges of translating xenotransplantation

R Thom, D Ayares, DKC Cooper, J Dark… - Journal of medical …, 2024 - jme.bmj.com
This manuscript reports on a landmark symposium on the ethical, legal and technical
challenges of xenotransplantation in the UK. King's College London, with endorsement from …

The 2021 IXA Keith Reemtsma Lecture: moving xenotransplantation to the clinic

DKC Cooper - Xenotransplantation, 2022 - Wiley Online Library
Keith Reemtsma was a pioneer in xenotransplantation, the Honorary Founding President of
the International Xenotransplantation Association (in 1998), and a wonderful personality. It is …

[HTML][HTML] Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations

D de Jongh, RL Thom, AJ Cronin… - Transplant …, 2023 - frontierspartnerships.org
The field of regenerative medicine offers potential therapies for Type 1 Diabetes, whereby
metabolically active cellular components are combined with synthetic medical devices …

The potential of genetically engineered pig heart transplantation in infants with complex congenital heart disease

SS Raza, H Hara, DC Cleveland… - Pediatric …, 2022 - Wiley Online Library
Despite advances in surgical and medical techniques, complex congenital heart disease in
neonates and infants continues to be associated with significant mortality and morbidity …

Barriers toward xenotransplantation in Arab World

M Ghazi, A Saleh, M Abdallah, D El Masri… - …, 2024 - Wiley Online Library
Organ transplant is a crucial therapeutic strategy offering a life‐saving and transformative
medical intervention. It provides an opportunity to improve their quality of life and increase …

Pressing ethical issues relating to clinical pig organ transplantation studies

DJ Hurst, DKC Cooper - Xenotransplantation, 2024 - Wiley Online Library
Clinical pig heart transplant experiments have been undertaken, and further clinical
experiments and/or clinical trials of gene‐edited pig organ xenotransplantation are …