The lung microenvironment: an important regulator of tumour growth and metastasis
NK Altorki, GJ Markowitz, D Gao, JL Port… - Nature Reviews …, 2019 - nature.com
Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …
deaths worldwide. Major advances in the identification of key mutational alterations have led …
Hypoxia-targeted drug delivery
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
Molecular imaging of the tumor microenvironment
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …
and resistance to therapy. It is different from normal tissue in the extracellular matrix …
Naturally-occurring canine mammary tumors as a translational model for human breast cancer
M Gray, J Meehan, C Martínez-Pérez, C Kay… - Frontiers in …, 2020 - frontiersin.org
Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …
worldwide health concern. Advances in pre-clinical and clinical research has led to …
Tumour microenvironment responsive nanoconstructs for cancer theranostic
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …
In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging
DL Longo, A Bartoli, L Consolino, P Bardini, F Arena… - Cancer research, 2016 - AACR
The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …
[HTML][HTML] Implantable biosensors and their contribution to the future of precision medicine
M Gray, J Meehan, C Ward, SP Langdon… - The Veterinary …, 2018 - Elsevier
Precision medicine can be defined as the prevention, investigation and treatment of
diseases taking individual variability into account. There are multiple ways in which the field …
diseases taking individual variability into account. There are multiple ways in which the field …
[HTML][HTML] Smart magnetic resonance imaging-based theranostics for cancer
Smart theranostics are dynamic platforms that integrate multiple functions, including at least
imaging, therapy, and responsiveness, in a single agent. This review showcases a variety of …
imaging, therapy, and responsiveness, in a single agent. This review showcases a variety of …
Lipid-based microbubbles and ultrasound for therapeutic application
D Omata, J Unga, R Suzuki, K Maruyama - Advanced Drug Delivery …, 2020 - Elsevier
Microbubbles with diagnostic ultrasound have had a long history of use in the medical field.
In recent years, the therapeutic application of the combination of microbubbles and …
In recent years, the therapeutic application of the combination of microbubbles and …
Targeted radiosensitizers for MR-guided radiation therapy of prostate cancer
Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related
damage to healthy tissue, it requires high precision in tumor localization and radiation dose …
damage to healthy tissue, it requires high precision in tumor localization and radiation dose …