The lung microenvironment: an important regulator of tumour growth and metastasis

NK Altorki, GJ Markowitz, D Gao, JL Port… - Nature Reviews …, 2019 - nature.com
Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Hypoxia-targeted drug delivery

A Sharma, JF Arambula, S Koo, R Kumar… - Chemical Society …, 2019 - pubs.rsc.org
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Molecular imaging of the tumor microenvironment

Z Zhou, ZR Lu - Advanced Drug Delivery Reviews, 2017 - Elsevier
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Naturally-occurring canine mammary tumors as a translational model for human breast cancer

M Gray, J Meehan, C Martínez-Pérez, C Kay… - Frontiers in …, 2020 - frontiersin.org
Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …

Tumour microenvironment responsive nanoconstructs for cancer theranostic

A Gulzar, J Xu, C Wang, F He, D Yang, S Gai, P Yang… - Nano today, 2019 - Elsevier
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …

In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging

DL Longo, A Bartoli, L Consolino, P Bardini, F Arena… - Cancer research, 2016 - AACR
The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …

[HTML][HTML] Implantable biosensors and their contribution to the future of precision medicine

M Gray, J Meehan, C Ward, SP Langdon… - The Veterinary …, 2018 - Elsevier
Precision medicine can be defined as the prevention, investigation and treatment of
diseases taking individual variability into account. There are multiple ways in which the field …

[HTML][HTML] Smart magnetic resonance imaging-based theranostics for cancer

B Brito, TW Price, J Gallo, M Bañobre-López… - Theranostics, 2021 - ncbi.nlm.nih.gov
Smart theranostics are dynamic platforms that integrate multiple functions, including at least
imaging, therapy, and responsiveness, in a single agent. This review showcases a variety of …

Lipid-based microbubbles and ultrasound for therapeutic application

D Omata, J Unga, R Suzuki, K Maruyama - Advanced Drug Delivery …, 2020 - Elsevier
Microbubbles with diagnostic ultrasound have had a long history of use in the medical field.
In recent years, the therapeutic application of the combination of microbubbles and …

Targeted radiosensitizers for MR-guided radiation therapy of prostate cancer

D Luo, A Johnson, X Wang, H Li, BO Erokwu… - Nano …, 2020 - ACS Publications
Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related
damage to healthy tissue, it requires high precision in tumor localization and radiation dose …