Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Innate immune surveillance of cancer involves multiple types of immune cells including the
innate lymphoid cells (ILCs). Natural killer (NK) cells are considered the most active ILC …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

It has been widely acknowledged that the use of immune checkpoint inhibitors (ICI) is an
effective therapeutic treatment in many late-stage cancers. However, not all patients could …

Abstract NK cells and CD8 T cells are cytotoxic lymphocytes that have critical protective
roles against pathogens and cancers. NK cells are conventionally regarded as rapid-acting …

I declare that the work submitted presented herein describes work that was performed
personally for the purpose of this thesis. Where other individuals have aided has been …

Mouse cytomegalovirus (MCMV) is a herpes virus that provides a useful model for studying
viral pathogenesis in multiple organs following a primary infection. It also enables tracking of …