Association between cervical microbiota and HPV: could this be the key to complete cervical cancer eradication?

E Cascardi, G Cazzato, A Daniele, E Silvestris… - Biology, 2022 - mdpi.com
Simple Summary The microbiota can modulate immune responses and modify the
physiology of the human organism, thereby increasing infective risks and a neoplastic …

Microbiome and cervical cancer

CP Castanheira, ML Sallas, RAL Nunes, NPC Lorenzi… - Pathobiology, 2021 - karger.com
Persistent infection with some types of mucosal human papillomavirus (HPV) is the
etiological factor for the development of cervical cancer and its precursor lesions. Besides …

Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study

A Audirac-Chalifour, K Torres-Poveda… - PloS one, 2016 - journals.plos.org
Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the
immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota …

Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of …

CM Wheeler, X Castellsagué, SM Garland… - The lancet …, 2012 - thelancet.com
Background We evaluated the efficacy of the human papillomavirus HPV-16/18 AS04-
adjuvanted vaccine against non-vaccine oncogenic HPV types in the end-of-study analysis …

Estimated prevalence and incidence of disease-associated human papillomavirus types among 15-to 59-year-olds in the United States

RM Lewis, JF Laprise, JW Gargano… - Sexually transmitted …, 2021 - journals.lww.com
Methods Prevalence and incidence were estimated for infections with any HPV (any of 37
types detected using Linear Array) and disease-associated HPV, 2 types that cause …

[HTML][HTML] PD-L1 expression correlates with tumor infiltrating lymphocytes and response to neoadjuvant chemotherapy in cervical cancer

Y Meng, H Liang, J Hu, S Liu, X Hao, MSK Wong… - Journal of …, 2018 - ncbi.nlm.nih.gov
Abstract Programmed death-ligand 1 (PD-L1) has been reported to be expressed in many
types of tumor cells, and bind to PD-1 on T lymphocytes to inhibit immune response …

Increased expression of programmed death (PD)‐1 and its ligand PD‐L1 correlates with impaired cell‐mediated immunity in high‐risk human papillomavirus‐related …

W Yang, Y Song, YL Lu, JZ Sun, HW Wang - Immunology, 2013 - Wiley Online Library
Impaired local cellular immunity contributes to the pathogenesis of persistent high‐risk
human papillomavirus (HR‐HPV) infection and related cervical intraepithelial neoplasia …

Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study

S Rachel Skinner, CM Wheeler… - … journal of cancer, 2016 - Wiley Online Library
The control arm of the phase III VIVIANE (Human PapillomaVIrus: Vaccine Immunogenicity
ANd Efficacy; NCT00294047) study in women> 25 years was studied to assess risk of …

Microbiota and HPV: The role of viral infection on vaginal microbiota

B Santella, MT Schettino, G Franci… - Journal of medical …, 2022 - Wiley Online Library
Abstract The World Health Organization (WHO) estimates that the prevalence of human
papillomaviruses (HPV) infection is between 9% and 13% of the world population and only …

Attribution of 12 high-risk human papillomavirus genotypes to infection and cervical disease

EA Joura, KA Ault, FX Bosch, D Brown, J Cuzick… - … Biomarkers & Prevention, 2014 - AACR
Background: We estimated the prevalence and incidence of 14 human papillomavirus (HPV)
types (6/11/16/18/31/33/35/39/45/51/52/56/58/59) in cervicovaginal swabs, and the …